Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles
Enqi He, Keimpe Wierda, Rhode van Westen and 4 more
Nature Communications · 2017
doi:10.1038/ncomms15915 (opens in a new tab)
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Abstract
The molecular mechanism underlying the generation and maintenance of the readily releasable pool composed of primed synaptic vesicles is only partially known. Here the authors show that in mouse primary neurons, Munc13-1 and Munc18-1 stabilize primed synaptic vesicles by preventing NSF-dependent de-priming.
Abstract licence: CC BY-NC-ND
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