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Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing

Rutger C. C. Hengeveld, Martijn J. M. Vromans, Mathijs Vleugel and 2 more

Nature Communications · 2017

doi:10.1038/ncomms15542 (opens in a new tab)

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Abstract

Precise chromosome segregation during mitosis requires coordination of stable chromosome bi-orientation with anaphase onset, however the underlying mechanism is not clear. Here the authors show that inner centromere localization of the chromosomal passenger complex maintains centromeric cohesion on bi-oriented chromosomes and allows mitotic checkpoint silencing.

Abstract licence: CC BY-NC-ND

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