Loss of Asxl2 leads to myeloid malignancies in mice
Jianping Li, Fuhong He, Peng Zhang and 20 more
Nature Communications · 2017
doi:10.1038/ncomms15456 (opens in a new tab)
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Abstract
ASXL2 mutations are mostly found in a subset of leukemia patients with certain genetic aberrations; however the role of this protein in normal hematopoiesis and related malignancies is still unclear. Here the authors use a knock-out mouse model to uncover the role of Asxl2in hematopoiesis and leukemogenesis.
Abstract licence: CC BY-NC-ND
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