Mistranslation can enhance fitness through purging of deleterious mutations
Sinisa Bratulic, Macarena Toll-Riera, Andreas Wagner
Nature Communications · 2017
doi:10.1038/ncomms15410 (opens in a new tab)
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Abstract
Mistranslation results in amino acid changes in proteins known as phenotypic mutations and these occur at a much higher rate than DNA mutations. Here, the authors show that mistranslation can increase the response to directional selection by exacerbating the fitness effects of deleterious DNA mutations.
Abstract licence: CC BY-NC-ND
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