Molecular basis for PrimPol recruitment to replication forks by RPA
Thomas A. Guilliam, Nigel C. Brissett, Aaron Ehlinger and 7 more
Nature Communications · 2017
doi:10.1038/ncomms15222 (opens in a new tab)
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Abstract
PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which stimulates its primase activity.
Abstract licence: CC BY-NC-ND
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