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Molecular basis for PrimPol recruitment to replication forks by RPA

Thomas A. Guilliam, Nigel C. Brissett, Aaron Ehlinger and 7 more

Nature Communications · 2017

doi:10.1038/ncomms15222 (opens in a new tab)

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Abstract

PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which stimulates its primase activity.

Abstract licence: CC BY-NC-ND

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