Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
Feng Pan, Thomas S. Wingo, Zhigang Zhao and 25 more
Nature Communications · 2017
doi:10.1038/ncomms15102 (opens in a new tab)
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Abstract
TET2 catalyses DNA demethylation and is mutated in various blood cancers; in particularTet2null mice develop haematological neoplasms. Here the authors show that this effect could be due to the increased frequency of mutation associated with TET2 loss in haematopoietic stem/progenitor cells.
Abstract licence: CC BY-NC-ND
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