RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
Heehwa G. Son, Mihwa Seo, Seokjin Ham and 14 more
Nature Communications · 2017
doi:10.1038/ncomms14749 (opens in a new tab)
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Abstract
The decline of DNA and protein quality control contributes to organismal ageing. Here, Sonet al. report that nonsense-mediated mRNA decay, a RNA quality control mechanism, is enhanced in long-lived daf-2 mutant worms and contributes to their longevity by regulating expression of the yars-2/tyrosyl tRNA synthetase.
Abstract licence: CC BY-NC-ND
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