Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection
Claire B. Péan, Mark Schiebler, Sharon W. S. Tan and 11 more
Nature Communications · 2017
doi:10.1038/ncomms14642 (opens in a new tab)
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Abstract
Cytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplet homeostasis.
Abstract licence: CC BY-NC-ND
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