Drebrin-mediated microtubule–actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection
Niraj Trivedi, Daniel R. Stabley, Blake Cain and 7 more
Nature Communications · 2017
doi:10.1038/ncomms14484 (opens in a new tab)
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Abstract
Neuronal migration is vital for neuronal circuit morphogenesis and is thought to rely on microtubule-actomyosin crosstalk. Here, the authors use super-resolution imaging and the drebrin microtubule-actin crosslinking protein to show that microtubule-actomyosin coupling controls the direction of centrosome and somal motility.
Abstract licence: CC BY-NC-ND
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