Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma
Huai-Qiang Ju, Haoqiang Ying, Tian Tian and 16 more
Nature Communications · 2017
doi:10.1038/ncomms14437 (opens in a new tab)
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Abstract
Kras activation and p16 inactivation cooperatively promote pancreatic cancer progression. Here, the authors show that such cooperation depends upon an increased expression of the NAD(P)H oxidase NOX4 achieved through transcription factors independently regulated by the two oncogenic genetic alterations.
Abstract licence: CC BY-NC-ND
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