Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model
Ferzin Sethna, Wei Feng, Qi Ding and 3 more
Nature Communications · 2017
doi:10.1038/ncomms14359 (opens in a new tab)
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Abstract
Fragile X syndrome (FXS) is a leading cause of autism and neurons lacking FMRP show aberrant mRNA translation and intracellular signalling. Here, the authors show that neurons from Fmr1 knockout mice have increased levels of ADCY1 protein, producing abnormal ERK1/2 signalling, dysregulated protein synthesis and behavioural symptoms associated with FXS.
Abstract licence: CC BY-NC-ND
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