Phylointeractomics reconstructs functional evolution of protein binding
Dennis Kappei, Marion Scheibe, Maciej Paszkowski-Rogacz and 8 more
Nature Communications · 2017
doi:10.1038/ncomms14334 (opens in a new tab)
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Abstract
Since protein interactions can be sensitive to small sequence changes, phylogenomics alone gives limited insight into protein functional evolution. Here, the authors illustrate how the combination of phylogenomics and interaction proteomics helps elucidate protein functional evolution with a study of the shelterin complex evolution.
Abstract licence: CC BY-NC-ND
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