Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
Michael J. Mitchell, Jamie Webster, Amanda Chung and 3 more
Nature Communications · 2017
doi:10.1038/ncomms14179 (opens in a new tab)
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Abstract
Fluid shear stress plays a critical role in receptor-mediated signalling and has been shown to sensitize cancer cells to apoptosis. Here, Mitchellet al. introduce polymer micro- and nanoparticles tethered to tumour cells to amplify fluid shear stress effects, and find that they can enhance immune cytokine-mediated apoptosis of tumour cells in vitro and in vivo.
Abstract licence: CC BY-NC-ND
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