Divergent prion strain evolution driven by PrPC expression level in transgenic mice
Annick Le Dur, Thanh Lan Laï, Marie-George Stinnakre and 12 more
Nature Communications · 2017
doi:10.1038/ncomms14170 (opens in a new tab)
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Abstract
PrPC protein plays a key role in prion transmission across species. Here, the authors compare transmission of a representative scrapie isolate to transgenic mice expressing variable levels of the same Prnp allele as the donor sheep, and find divergent strain propagation regulated by PrPCgene dosage.
Abstract licence: CC BY-NC-ND
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