mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
Victor H. Villar, Tra Ly Nguyen, Vanessa Delcroix and 8 more
Nature Communications · 2017
doi:10.1038/ncomms14124 (opens in a new tab)
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Abstract
Inhibitors of the mTORC1 pathway are considered anti-cancer drugs. Here, the authors show that on nutrient restriction, glutaminolysis-induced activation of mTORC1 induces apoptosis via inhibiting autophagy, highlighting that under such conditions inhibition of mTORC1 results in survival of cancer cells.
Abstract licence: CC BY-NC-ND
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