Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
Anren Song, Yujin Zhang, Leng Han and 26 more
Nature Communications · 2017
doi:10.1038/ncomms14108 (opens in a new tab)
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Abstract
Humans that reach high altitude soon after the first ascent show faster adaptation to hypoxia. Songet al. show that this adaptive response relies on decreased red blood cell uptake of plasma adenosine due to reduced levels of nucleoside transporter ENT1 resulting from coordinated adenosine generation by ectonucleotidase CD73 and activation of A2B receptors.
Abstract licence: CC BY-NC-ND
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