Structural basis of human PCNA sliding on DNA
Matteo De March, Nekane Merino, Susana Barrera-Vilarmau and 4 more
Nature Communications · 2017
doi:10.1038/ncomms13935 (opens in a new tab)
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Abstract
DNA sliding clamps are ring-shaped proteins that encircle DNA and harbour polymerases and other factors that promote processive DNA replication. Here the authors use X-ray crystallography, NMR and MD simulations to propose a model for a PCNA sliding mechanism that relies on short-lived polar interactions.
Abstract licence: CC BY-NC-ND
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