p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis
Robert A.H. van de Ven, Jolien S. de Groot, Danielle Park and 11 more
Nature Communications · 2016
doi:10.1038/ncomms13874 (opens in a new tab)
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Abstract
The tumour suppressor p120-catenin (p120) controls cadherin-based adhesion. Here, the authors demonstrate that p120 regulates cytokinesis through binding to the centralspindlin component MKLP1 and controls RhoA activity. Loss of p120 in cancer induces multinucleation and chromosomal instability, independent of cell-cell adhesion.
Abstract licence: CC BY-NC-ND
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