Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53
Tengfei Chao, Xiang Zhou, Bo Cao and 6 more
Nature Communications · 2016
doi:10.1038/ncomms13755 (opens in a new tab)
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Abstract
p53 is an oncosuppressor regulating several genes at the transcriptional level. Here, the authors identify a negative feedback loop between PHLDB3 and p53; PHLDB3 is a transcriptional target of p53 which facilitates MDM2-mediated p53 ubiquitination and degradation, impacting on tumorigenesis.
Abstract licence: CC BY-NC-ND
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