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Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction

Marie A. Hanebuth, Roman Kityk, Sandra J. Fries and 8 more

Nature Communications · 2016

doi:10.1038/ncomms13695 (opens in a new tab)

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Abstract

The correct folding of proteins often requires the intervention molecular chaperones, which can occur co-translationally. Here the authors identify elements of yeast Ssb (Hsp70) that mediate ribosomal binding, and suggest a mechanism that directs efficient interaction of Ssb with the nascent chain.

Abstract licence: CC BY-NC-ND

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