Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge

Plasma cells produce secreted antibodies and are thought to lack expression of the membrane-bound immunoglobulins that constitute B-cell receptors. Here the authors show that IgM-expressing plasma cells maintain B-cell receptor expression and initiate cytokine production following antigen stimulation.

Abstract licence: CC BY-NC-ND

• Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) · 2021

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