VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination
Yuki Miyamoto, Tomohiro Torii, Akito Tanoue and 1 more
Nature Communications · 2016
doi:10.1038/ncomms13478 (opens in a new tab)
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Abstract
The vascular cell adhesion molecule VCAM1 plays a role in the immune system but is also expressed in oligodendrocytes. Here, the authors find VCAM1 interacts with neuronal α4 integrin to regulate oligodendrocyte differentiation and thereby myelination, an effect mediated by downstream CD69 signalling.
Abstract licence: CC BY-NC-ND
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