Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability
Jodi R. Paul, Daniel DeWoskin, Laura J. McMeekin and 3 more
Nature Communications · 2016
doi:10.1038/ncomms13470 (opens in a new tab)
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Abstract
It is not clear how circadian biochemical cascades are encoded into neural electrical signals. Here, using a combination of electrophysiology and modelling approaches in mice, the authors show activation of glycogen synthase kinase 3 modulates neural activity in the suprachiasmatic nuclei via regulation of the persistent sodium current, INaP.
Abstract licence: CC BY-NC-ND
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