Reader domain specificity and lysine demethylase-4 family function
Zhangli Su, Fengbin Wang, Jin-Hee Lee and 12 more
Nature Communications · 2016
doi:10.1038/ncomms13387 (opens in a new tab)
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Abstract
KDM4 histone demethylases target specific chromatin regions by a mechanism that is not fully characterised. Here, the authors identify trimethyl-lysine histone-binding preferences for closely related KDM4 double tudor domains and use structural and biochemical information to examine the molecular details of this interaction.
Abstract licence: CC BY-NC-ND
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