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CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells

Jae-Ho Cho, Hee-Ok Kim, Young-Jun Ju and 10 more

Nature Communications · 2016

doi:10.1038/ncomms13373 (opens in a new tab)

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Abstract

Naïve T cells establish self-tolerance via negative selection of cells with strong reactivity for self-peptide/MHC complexes, but undergo T-cell receptor (TCR) desensitisation when leaving the thymus. Here, Choet al.show that TCR desensitisation correlates with cell-surface density of the phosphatase CD45.

Abstract licence: CC BY-NC-ND

References51

  1. 13.

    Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction · 2010

39 more references, whose wording the paper’s licence keeps private.

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