Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication
Kan Xing Wu, Patchara Phuektes, Pankaj Kumar and 5 more
Nature Communications · 2016
doi:10.1038/ncomms13150 (opens in a new tab)
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Abstract
Enterovirus 71 (EV71) infection causes a spectrum of symptoms including neurological disease. To improve our understanding of EV71-host interactions, Wu et al. here perform a genome-wide RNAi screen, which implicates cell cycle regulation and ER-associated degradation as important factors in EV71 replication.
Abstract licence: CC BY-NC-ND
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