Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel
Awani Upadhyay, Aditya Pisupati, Timothy Jegla and 8 more
Nature Communications · 2016
doi:10.1038/ncomms13135 (opens in a new tab)
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Abstract
TRPV are cation channels activated by physical and chemical stimuli. Here the authors show that nicotinamide is a soluble, endogenous agonist for orthologous TRPV channels fromC. elegans and Drosophila, unveiling a metabolic-based regulation for TRPV channel activity.
Abstract licence: CC BY-NC-ND
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