PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells
Corina T. Madreiter-Sokolowski, Christiane Klec, Warisara Parichatikanond and 11 more
Nature Communications · 2016
doi:10.1038/ncomms12897 (opens in a new tab)
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Abstract
MICU1 is a regulatory subunit of mitochondrial Ca2+ channels that shields mitochondria from Ca2+ overload. Here the authors show that MICU1 methylation by PRMT1 reduces Ca2+ sensitivity, which is normalized by UCP2/3, re-establishing mitochondrial Ca2+uptake activity.
Abstract licence: CC BY-NC-ND
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