CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages
Milton Pereira, Panagiotis Tourlomousis, John Wright and 2 more
Nature Communications · 2016
doi:10.1038/ncomms12874 (opens in a new tab)
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Abstract
IL-1β is important for control of bacterial infections, but when deregulated can lead to excessive inflammation. The authors show that the adaptor protein CARD9 suppresses levels of IL-1β and is downregulated during S. Typhimuriuminfection, thus facilitating an inflammatory response
Abstract licence: CC BY-NC-ND
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