Stratification and therapeutic potential of PML in metastatic breast cancer
Natalia Martín-Martín, Marco Piva, Jelena Urosevic and 36 more
Nature Communications · 2016
doi:10.1038/ncomms12595 (opens in a new tab)
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Abstract
Targeting PML in acute promyelocytic leukaemia has changed the outcome of patients with this disease. Here, the authors demonstrated that PML is also a potential therapeutic target in breast cancer where it specifically regulates cancer initiating cells and tumour progression through the transcriptional regulation of SOX9.
Abstract licence: CC BY-NC-ND
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