MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
Irene Moretti, Stefano Ciciliot, Kenneth A. Dyar and 13 more
Nature Communications · 2016
doi:10.1038/ncomms12397 (opens in a new tab)
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Abstract
Mrf4 is a transcription factor important for muscle development, but despite high expression its function in adults is unknown. Here the authors show that interfering with Mrf4 in adult mice leads to muscle hypertrophy by activating MEF2-dependent transcription and promoting protein synthesis.
Abstract licence: CC BY-NC-ND
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