Magneto-nanosensor platform for probing low-affinity protein–protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction
Jung-Rok Lee, Daniel J. B. Bechstein, Chin Chun Ooi and 5 more
Nature Communications · 2016
doi:10.1038/ncomms12220 (opens in a new tab)
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Abstract
Measurement of low-affinity protein–protein interactions is challenging; surface plasmon resonance requires high concentrations of reagents. Here the authors combine magneto-nanosensors with microfluidic chips and protein-conjugated magnetic nanoparticles to discover a low-affinity interaction between T-cell inhibitory receptors PD-L1 and PD-L2.
Abstract licence: CC BY-NC-ND
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