Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
Bangwei Luo, Jinsong Wang, Zongwei Liu and 7 more
Nature Communications · 2016
doi:10.1038/ncomms12177 (opens in a new tab)
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Abstract
Hypoxia induced during inflammation promotes the resolution phase. Here the authors show that the hypoxia results from the respiratory burst in myeloid cells, and induces local EPO production and signaling, which enhances macrophage phagocytosis of debris and migration to draining lymph nodes to promote resolution.
Abstract licence: CC BY-NC-ND
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