Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics
Eloy F. Robles, Maria Mena-Varas, Laura Barrio and 41 more
Nature Communications · 2016
doi:10.1038/ncomms11889 (opens in a new tab)
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Abstract
The homeobox NKX2 family of transcriptional factors has been shown to regulate fundamental developmental processes. Here, the authors show that NKX2-3 is a bona fideoncogenic driver in marginal-zone B-cell lymphoma and that it promotes lymphomagenesis by shaping lymphocyte dynamics and promoting BCR signalling.
Abstract licence: CC BY-NC-ND
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