BK channels in microglia are required for morphine-induced hyperalgesia
Yoshinori Hayashi, Saori Morinaga, Jing Zhang and 7 more
Nature Communications · 2016
doi:10.1038/ncomms11697 (opens in a new tab)
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Abstract
Long-term use of opioids can lead to a paradoxical increase in pain sensitivity. Here, Hayashi et al. link activation of potassium channels on microglia with morphine-induced hyperalgesia and anti-nociceptive tolerance in mice.
Abstract licence: CC BY-NC-ND
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