Structure of human Cdc45 and implications for CMG helicase function
Aline C. Simon, Vincenzo Sannino, Vincenzo Costanzo and 1 more
Nature Communications · 2016
doi:10.1038/ncomms11638 (opens in a new tab)
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Abstract
The cell cycle division protein Cdc45 is required for genome duplication in eukaryotes. Here, the authors determine the crystal structure of human Cdc45 and combine it with functional data to improve our understanding of its role in DNA replication.
Abstract licence: CC BY-NC-ND
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