ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation
Petrus R. de Jong, Koji Taniguchi, Alexandra R. Harris and 8 more
Nature Communications · 2016
doi:10.1038/ncomms11551 (opens in a new tab)
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Abstract
It is unclear how the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathways interact with other signals in intestinal epithelial cells. Here, the authors show that upon loss of Erk1/2, or pharmacological inhibition of MEK1/2, the ERK5 pathway is upregulated to maintain epithelial cell proliferation.
Abstract licence: CC BY-NC-ND
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