Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration
Nathan D. Jones, Miguel A. Lopez Jr, Jeungphill Hanne and 4 more
Nature Communications · 2016
doi:10.1038/ncomms11409 (opens in a new tab)
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Abstract
Retroviral Integration into the host DNA is a rare event with evidence suggesting that it relies on DNA topology and sequence. Here the authors present single molecule evidence that shows the retroviral integration machinery vigorously scans the target DNA by 1D-diffusion but infrequently integrates.
Abstract licence: CC BY-NC-ND
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