PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity
Eyad Kalawy Fansa, Stefanie Kristine Kösling, Eldar Zent and 2 more
Nature Communications · 2016
doi:10.1038/ncomms11366 (opens in a new tab)
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Abstract
PDE6δ regulates the sorting of prenylated cargo proteins. Here Fansa et al. propose that the affinity of the interaction between PDE6δ and its cargo protein determines whether they are released by cytoplasmic or cilia-specific release factors ultimately determining their subcellular localization.
Abstract licence: CC BY-NC-ND
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