Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
Wook-Bin Lee, Ji-Seon Kang, Won Young Choi and 5 more
Nature Communications · 2016
doi:10.1038/ncomms11322 (opens in a new tab)
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Abstract
Resolution of granulomas in mycobacterial infection requires macrophages to switch from cytokine to nitric oxide (NO) production. Here the authors show that Mincle stimulates translation of the key NO synthesis genes by a mechanism dependent on p38-mediated hypusination of eiF5A.
Abstract licence: CC BY-NC-ND
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