Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering
Franka Voigt, Lisa Wiedemann, Cecilia Zuliani and 6 more
Nature Communications · 2016
doi:10.1038/ncomms11126 (opens in a new tab)
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Abstract
Sleeping Beauty is used as a genome engineering tool in a range of organisms. Here, the authors solve an atomic structure of Sleeping Beauty (SB) transposase and model the target DNA into the active site, elucidating details that may enable the rational design of novel transposases.
Abstract licence: CC BY-NC-ND
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