The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
Mariam H. Orme, Gianmaria Liccardi, Nina Moderau and 17 more
Nature Communications · 2016
doi:10.1038/ncomms10972 (opens in a new tab)
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Abstract
In addition to their role in apoptosis, caspases are also involved in mediating non-apoptotic events. Here the authors show that the Drosophilamyosin family member CRINKLED and its mammalian counterpart act as substrate adaptor that facilitate caspase-mediated cleavage and localised kinase activity.
Abstract licence: CC BY-NC-ND
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