Production of unstable proteins through the formation of stable core complexes
Nicolas Levy, Sylvia Eiler, Karine Pradeau-Aubreton and 3 more
Nature Communications · 2016
doi:10.1038/ncomms10932 (opens in a new tab)
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Abstract
Flexible or disordered domains often hinder the purification of proteins involved in functional interactions. Here the authors describe an approach that enables the production of stable and functional complexes of otherwise unstable proteins in quantities sufficient for structural and functional studies.
Abstract licence: CC BY-NC-ND
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