A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
Nicoletta I. Petridou, Paris A. Skourides
Nature Communications · 2016
doi:10.1038/ncomms10899 (opens in a new tab)
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Abstract
During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.
Abstract licence: CC BY-NC-ND
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