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ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries

Josephine Bowles, Chun-Wei Feng, Kim Miles and 3 more

Nature Communications · 2016

doi:10.1038/ncomms10845 (opens in a new tab)

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Abstract

Recent findings have challenged the established concept that retinoic acid (RA) induces foetal germ cells to enter meiosis. Here, Bowles et al. identify the enzyme ALDH1A1 as a source of ovarian RA that may induce meiosis even when other RA-synthetic enzymes are deleted.

Abstract licence: CC BY-NC-ND

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