Hypothalamic leptin action is mediated by histone deacetylase 5
Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García-Cáceres and 24 more
Nature Communications · 2016
doi:10.1038/ncomms10782 (opens in a new tab)
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Abstract
Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3.
Abstract licence: CC BY-NC-ND
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