SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication
David Walter, Saskia Hoffmann, Eirini-Stavroula Komseli and 3 more
Nature Communications · 2016
doi:10.1038/ncomms10530 (opens in a new tab)
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Abstract
To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.
Abstract licence: CC BY-NC-ND
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