Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
Petra Hartmann, Zhe Zhou, Lucia Natarelli and 7 more
Nature Communications · 2016
doi:10.1038/ncomms10521 (opens in a new tab)
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Abstract
The RNAse III endonuclease Dicer is crucial for processing of pre-miRNAs in health and disease. Here the authors show that endothelial Dicer promotes atherosclerosis by increasing miR-103 levels leading to suppression of the anti-inflammatory transcription factor KLF4, thus suggesting a novel approach to treat this disease.
Abstract licence: CC BY-NC-ND
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