Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding

Export of Plasmodium falciparum proteins into infected erythrocytes relies upon the PEXEL motif in target proteins. Here Boddey et al.challenge the hypothesis that the PEXEL motif mediates export by binding PI(3)P and instead suggest it acts via cleavage by plasmepsin V.

Abstract licence: CC BY-NC-ND

1. 5.

   Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites · 2014

2. 8.

   Identification of New PNEPs Indicates a Substantial Non-PEXEL Exportome and Underpins Common Features in Plasmodium falciparum Protein Export · 2013

3. 23.

   Inducible Knockdown of Plasmodium Gene Expression Using the glmS Ribozyme · 2013

4. 31.

   The Malarial Host-Targeting Signal Is Conserved in the Irish Potato Famine Pathogen · 2006

5. 39.

   Role of the Plasmodium Export Element in Trafficking Parasite Proteins to the Infected Erythrocyte · 2009

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