Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion
Yusuke Yamamoto, Xia Wang, Denis Bertrand and 18 more
Nature Communications · 2016
doi:10.1038/ncomms10380 (opens in a new tab)
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Abstract
Barrett’s oesophagus is a precancerous intestinal metaplasia that can progress to oesophageal adenocarcinoma. In this study, the authors isolate and characterize human Barrett’s stem cells and identify a specific genomic pedigree that supports the potential role of these cells as precursors of oesophageal adenocarcinoma.
Abstract licence: CC BY-NC-ND
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